What is the treatment for syphilis?

What is the treatment for syphilis?

• A. Amoxicillin
• B. Doxycycline
• C. Azithromycin
• D. Penicillin G

Answer: (D)

Penicillin G is the treatment of choice for syphilis because it reliably eradicates Treponema pallidum and has the strongest evidence of effectiveness across all stages. For early syphilis, a single dose of benzathine penicillin G often cures the infection; for late latent or tertiary disease, a longer course with weekly doses is used; and for neurosyphilis, high‑dose intravenous penicillin G is required to achieve adequate central nervous system levels. While alternatives like doxycycline or amoxicillin can be considered in penicillin-allergic patients, they are not as reliably effective, and azithromycin resistance in Treponema pallidum limits its use.

Penicillin G is the treatment of choice for syphilis because it reliably eradicates Treponema pallidum and has the strongest evidence of effectiveness across all stages. For early syphilis, a single dose of benzathine penicillin G often cures the infection; for late latent or tertiary disease, a longer course with weekly doses is used; and for neurosyphilis, high‑dose intravenous penicillin G is required to achieve adequate central nervous system levels. While alternatives like doxycycline or amoxicillin can be considered in penicillin-allergic patients, they are not as reliably effective, and azithromycin resistance in Treponema pallidum limits its use.